NBC News announced Monday that Sheen will make a "revealing personal announcement" in an exclusive, live sit-down interview on Tuesday with Matt Lauer, but did not provide further details.
A rep for Sheen has not responded to USA TODAY's request for comment.
Sheen, 50, who in 2011 lost his starring role on Two and a Half Men amidst a notorious public meltdown, has remained largely out of the spotlight after FX decided not to renew his most recent show Anger Management, in late 2014. In his personal life, it was announced in October 2014 that he and adult film star Brett Rossi ended their eight-month engagement.
Charlie Sheen waves to fans as he leaves Hotel La Perla, where he and his partner are staying during the Festival of San Fermin in Pamplona, Spain, in July 2014.